High-Throughput Fluorescence-Based Screening Assays for Tryptophan-Catabolizing Enzymes
نویسندگان
چکیده
منابع مشابه
High-throughput fluorescence-based screening assays for tryptophan-catabolizing enzymes.
Indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO) are two structurally different enzymes that have a different tissue distribution and physiological roles, but both catalyze the conversion of tryptophan to N-formylkynurenine (NFK). IDO1 has been clinically validated as a small-molecule drug target for cancer, while preclinical studies indicate that TDO may be a target for ...
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Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that have independently evolved to catalyze the first step in tryptophan catabolism via the kynurenine pathway (KP). The depletion of tryptophan and formation of KP metabolites modulates the activity of the mammalian immune, reproductive, and central nervous systems. IDO and TDO enzymes can h...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 2014
ISSN: 1087-0571,1552-454X
DOI: 10.1177/1087057114536616